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etravirine will decrease the extent or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.crofelemer will increase amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Crofelemer has the potential to inhibit CYP3A4 at concentrations envisioned from the inte